8.55094

Trichloroacetimidate Wang resin

Novabiochem^®

• Synonyme(s) : Trichloroacetimidate Wang resin
• Numéro CAS: 89238-99-3
• Numéro MDL: MFCD00134547
• Code UNSPSC : 12352101
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 200
• Gamme de produits: Novabiochem^®
• Forme: beads
• Capacité de réaction: reaction type: Fmoc solid-phase peptide synthesis
• Fabricant/nom de marque: Novabiochem^®
• Application(s): peptide synthesis
• Température de stockage: 2-8°C
• InChI: 1S/C10H10Cl3NO2/c1-15-8-4-2-7(3-5-8)6-16-9(14)10(11,12)13/h2-5,14H,6H2,1H3
• Clé InChI: TYHGKLBJBHACOI-UHFFFAOYSA-N

Description

Description générale

A highly versatile reagent for the solid phase immobilization of alcohols ^[1,2,3]; carboxylic, phosphonic and sulfonic acids ^[4]; thiols and thioacids ^[4]; and phenols ^[5]. In contrast to the analogous bromide resin which is loaded under basic conditions, derivatization of this support is achieved under acidic conditions, making it compatible with base-sensitive compounds such as Fmoc-amino alcohols.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

^[1] S. Hanessian & X. Fang (1998) Tetrahedron Lett., 39, 733.
^[2] A. Bianco, et al. (2000) J. Comb. Chem., 2, 681.
^[3] A. Kamal, et al. (2002) Tetrahedron Lett., 43, 2103.
^[4] C. W. Phoon, et al. (1998) Tetrahedron Lett., 39, 7959.
^[5] A. Kamal, et al. (2001) Tetrahedron Lett., 42, 6969.

Liaison

Replaces: 01-64-0314

Remarque sur l'analyse

Color (visual): slight yellow to beige
Appearance of substance (visual): beads
Loading (determined by elemental analysis after derivatization with thioacetic acid): 0.60 - 1.20 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene-1% DVB), 100 - 200 mesh

Informations légales

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable