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Sigma-Aldrich

NanoFabTx Polymers for Microneedles

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Hyaluronic acid sodium salt

Synonyme(s) :

Hyaluronic acid sodium salt

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About This Item

Formule linéaire :
(C14H21NaNO11)n
Numéro CAS:

Niveau de qualité

Pureté

≥90%

Poids mol.

100-150 kDa

Température de stockage

2-8°C

Chaîne SMILES 

O[C@H]1[C@H](O[C@@H]2O[C@H](C(O[Na])=O)[C@@H](OC)[C@H](O)[C@H]2O)[C@@H](NC(C)=O)[C@H](C)O[C@@H]1CO

Application

NanoFabTx Polymers for Microneedles are carefully selected polymers that can be used to formulate microneedle patches. Microneedles are tiny projections of needles approximately 400-800um in length arranged in a small 1cm x 1cm patch. Microneedles are composed of blends of synthetic or natural polymers at suitable concentrations. Sodium hyaluronic acid (HA) is the derivate of a natural polymer and is a natural polysaccharide. It is a water-soluble polymer and is available in different molecular weights. The formation of the microneedles depends on the molecular weight and concentration of HA.


The NanoFabTx Polymers for Microneedles can be used with the microneedle templates to formulate microneedle that can be used for several applications, such as delivering various therapeutic molecules and vaccine antigens via the skin. The selected polymer will enable users to:

1)save time in selecting the polymer and provide a starting point to formulate microneedles by avoiding lengthy trial-and-error optimization.

2)formulate microneedles for various drug delivery applications.

Informations légales

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

A dual-delivery platform for vaccination using antigen-loaded nanoparticles in dissolving microneedles
Gomes K B, et al.
International Journal of Pharmaceutics, 613, 121393-121393 (2022)
Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development
Larra?eta E, et al.
Materials Science & Engineering. R, Reports : A Review Journal, 104, 1-32 (2016)
Keegan Braz Gomes et al.
International journal of pharmaceutics, 613, 121393-121393 (2021-12-21)
Effective vaccines delivered via painless methods would revolutionize the way people approach vaccinations. This study focused on the development of fast-dissolving microneedles (MNs) to deliver antigen-loaded sustained release polymeric nanoparticles (NPs), achieving a dual-delivery platform for vaccination through the skin.

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