Accéder au contenu
MilliporeSigma

UGT1A1

UDP glucuronosyltransferase 1 family, polypeptide A1

Synonymes:
BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(54658) Summary: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008]
  • Mouse(394436) UDP glucuronosyltransferase 1 family, polypeptide A1
  • Rat(24861) UDP glucuronosyltransferase 1 family, polypeptide A1
  • Zebrafish(641488) UDP glucuronosyltransferase 1 family polypeptide a1
  • chicken(424028) UDP glucuronosyltransferase 1 family, polypeptide A1
  • domestic cat(493955) UDP glucuronosyltransferase 1 family, polypeptide A1
  • Horse(100065342) UDP glucuronosyltransferase 1 family, polypeptide A1
  • cow(751790) UDP glucuronosyltransferase 1 family, polypeptide A1
  • sheep(100534644) UDP glucuronosyltransferase 1 family, polypeptide A1

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-UGT1A1, affinity isolated antibody,
Espèces réactives
human
Application
western blot

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human UGT1A1,
Espèce(s)
human