TJP3
tight junction protein 3
- Human(27134) Summary: The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]
- Mouse(27375) tight junction protein 3
- Rat(314640) tight junction protein 3
- naked mole-rat(101702864) tight junction protein 3
- dog(403852) tight junction protein 3
- Zebrafish(373089) tight junction protein 3
- chicken(420070) tight junction protein 3 (zona occludens 3)
- domestic cat(101098036) tight junction protein 3
- domestic guinea pig(100718150) tight junction protein 3
- cow(407100) tight junction protein 3 (zona occludens 3)
- Horse(100066918) tight junction protein 3
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