PTPN12
protein tyrosine phosphatase, non-receptor type 12
Synonymes:
PTP-PEST, PTPG1
Espèce(s):
Human PTPN12 (5782), Mouse Ptpn12 (19248), Rat Ptpn12 (117255), chicken PTPN12 (417725), cow PTPN12 (531877), sheep PTPN12 (101117497), Zebrafish ptpn12 (393642), Horse PTPN12 (100057833), domestic guinea pig Ptpn12 (100725572), domestic cat PTPN12 (101091096) ...Plus
ID UniProtKB:
ID du gène:
- Human(5782) Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
- Mouse(19248) protein tyrosine phosphatase, non-receptor type 12
- Rat(117255) protein tyrosine phosphatase, non-receptor type 12
- chicken(417725) protein tyrosine phosphatase, non-receptor type 12
- cow(531877) protein tyrosine phosphatase, non-receptor type 12
- sheep(101117497) protein tyrosine phosphatase, non-receptor type 12
- Zebrafish(393642) protein tyrosine phosphatase, non-receptor type 12
- Horse(100057833) protein tyrosine phosphatase, non-receptor type 12
- domestic guinea pig(100725572) protein tyrosine phosphatase, non-receptor type 12
- domestic cat(101091096) protein tyrosine phosphatase, non-receptor type 12
- dog(483277) protein tyrosine phosphatase, non-receptor type 12
- Domestic Rabbit(100350817) protein tyrosine phosphatase, non-receptor type 12
- naked mole-rat(101697685) protein tyrosine phosphatase, non-receptor type 12
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-PTP-PEST Antibody, clone AG25, ascites fluid, clone AG25, from mouse,
Espèces réactives
human, mouse, rat
Application
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-PTPN12 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PTPN12 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
western blot
Monoclonal Anti-Protein Tyrosine Phosphatase PEST antibody produced in mouse, clone AG25, purified immunoglobulin,
Espèces réactives
bovine, human, mouse, rat
Application
immunoprecipitation (IP)
western blot
western blot
Proteins
Référence du produit
Description
Espèce(s)
PTPN12 (1-355), active, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human