PTPN11
protein tyrosine phosphatase, non-receptor type 11
Synonymes:
BPTP3, CFC, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
Espèce(s):
Human PTPN11 (5781), Mouse Ptpn11 (19247), Rat Ptpn11 (25622), sheep PTPN11 (101114308), naked mole-rat Ptpn11 (101701336), dog PTPN11 (477488), domestic cat PTPN11 (101085500), chicken PTPN11 (395815), Horse PTPN11 (100056857), cow PTPN11 (533590)
ID UniProtKB:
ID du gène:
- Human(5781) Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
- Mouse(19247) protein tyrosine phosphatase, non-receptor type 11
- Rat(25622) protein tyrosine phosphatase, non-receptor type 11
- sheep(101114308) protein tyrosine phosphatase, non-receptor type 11
- naked mole-rat(101701336) protein tyrosine phosphatase, non-receptor type 11
- dog(477488) protein tyrosine phosphatase, non-receptor type 11
- domestic cat(101085500) protein tyrosine phosphatase, non-receptor type 11
- chicken(395815) protein tyrosine phosphatase, non-receptor type 11
- Horse(100056857) protein tyrosine phosphatase, non-receptor type 11
- cow(533590) protein tyrosine phosphatase, non-receptor type 11
- domestic guinea pig(100732797) protein tyrosine phosphatase, non-receptor type 11
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-SHP2 Antibody, clone 3B17 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
bovine, canine, horse, human, monkey, porcine, rat
Application
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Anti-SHP2 (ab1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-PTPN11 (AB2) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-PTPN11 (Ab-542) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-SH-PTP2 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Proteins
Référence du produit
Description
Espèce(s)