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PIK3R5

phosphoinositide-3-kinase, regulatory subunit 5

Synonymes:
F730038I15Rik, FOAP-2, P101-PI3K, p101
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(23533) Summary: Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]
  • Mouse(320207) phosphoinositide-3-kinase, regulatory subunit 5, p101
  • Rat(497931) phosphoinositide-3-kinase, regulatory subunit 5
  • cow(614838) phosphoinositide-3-kinase, regulatory subunit 5
  • Domestic Rabbit(100337757) phosphoinositide-3-kinase, regulatory subunit 5
  • domestic cat(101082354) phosphoinositide-3-kinase, regulatory subunit 5
  • dog(612805) phosphoinositide-3-kinase, regulatory subunit 5
  • domestic guinea pig(100729793) phosphoinositide-3-kinase, regulatory subunit 5
  • chicken(417319) phosphoinositide 3-kinase regulatory subunit 5
  • Zebrafish(323588) phosphoinositide-3-kinase, regulatory subunit 5
  • naked mole-rat(101721762) phosphoinositide-3-kinase, regulatory subunit 5
  • sheep(101109983) phosphoinositide-3-kinase, regulatory subunit 5
  • Horse(100062810) phosphoinositide-3-kinase, regulatory subunit 5

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Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-PIK3R5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-PIK3R5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
western blot
Anti-PIK3R5 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
proximity ligation assay
western blot
Anti-PIK3R5 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse
Application
ELISA
immunohistochemistry
Anti-PIK3R5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
PF-04691502, ≥98% (HPLC),
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human PIK3R5,
Espèce(s)
human
MISSION® esiRNA, targeting mouse Pik3r5,
Espèce(s)
mouse