NR1H3
nuclear receptor subfamily 1, group H, member 3
Synonymes:
LXR-a, LXRA, RLD-1
Espèce(s):
Human NR1H3 (10062), Mouse Nr1h3 (22259), Rat Nr1h3 (58852), chicken NR1H3 (395221), Zebrafish nr1h3 (548341), naked mole-rat Nr1h3 (101709627), domestic guinea pig Nr1h3 (100725013), Goat NR1H3 (100860906), sheep NR1H3 (101116762), cow NR1H3 (507176) ...Plus
ID UniProtKB:
ID du gène:
- Human(10062) Summary: The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
- Mouse(22259) nuclear receptor subfamily 1, group H, member 3
- Rat(58852) nuclear receptor subfamily 1, group H, member 3
- chicken(395221) nuclear receptor subfamily 1, group H, member 3
- Zebrafish(548341) nuclear receptor subfamily 1, group H, member 3
- naked mole-rat(101709627) nuclear receptor subfamily 1, group H, member 3
- domestic guinea pig(100725013) nuclear receptor subfamily 1, group H, member 3
- Goat(100860906) nuclear receptor subfamily 1, group H, member 3
- sheep(101116762) nuclear receptor subfamily 1, group H, member 3
- cow(507176) nuclear receptor subfamily 1, group H, member 3
- domestic cat(101092889) nuclear receptor subfamily 1, group H, member 3
- dog(483625) nuclear receptor subfamily 1, group H, member 3
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Small Molecule - Agonist
Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-LXR-A antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-LXR alpha Antibody, clone 2B7, clone 2B7, from mouse,
Espèces réactives
mouse, rat
Application
immunoprecipitation (IP)
western blot
western blot
Anti-NR1H3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Anti-NR1H3 antibody produced in rabbit, IgG fraction of antiserum,
Espèces réactives
human
Application
western blot
Anti-LXRα antibody produced in rabbit, ,
Espèces réactives
mouse, rat
Application
immunohistochemistry
western blot
western blot
Small Molecule - Mixed Agonist/Antagonist
Référence du produit
Description
Espèce(s)
Proteins
Référence du produit
Description
Espèce(s)
LXRα-ligand binding domain (215-667) human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Espèce(s)
human
LXR, α, ligand binding domain, GST tagged human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
Espèce(s)
human
LXR, α isoform, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Espèce(s)
human
LXR, α isoform, N-terminal region (1-182), GST tagged β human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
Espèce(s)
human