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Merck

MYLK

myosin light chain kinase

Synonymes:
AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(4638) Summary: This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
  • Mouse(107589) myosin, light polypeptide kinase
  • Rat(288057) myosin light chain kinase
  • domestic guinea pig(100714177) myosin light chain kinase
  • dog(488012) myosin light chain kinase
  • naked mole-rat(101704236) myosin light chain kinase
  • chicken(396445) myosin light chain kinase
  • Domestic Rabbit(100009143) myosin light chain kinase
  • sheep(443334) myosin light chain kinase
  • cow(338037) myosin light chain kinase
  • Horse(100070482) myosin light chain kinase

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Antibodies

Référence du produit
Description
Espèces réactives
Application
Monoclonal Anti-Myosin Light Chain Kinase antibody produced in mouse, clone K36, ascites fluid,
Espèces réactives
avian, mammals
Application
immunoprecipitation (IP)
microarray

western blot
Anti-MYLK antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
western blot
Anti-MYLK antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
Anti-MYLK antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human, mouse
Application
ELISA
western blot
Anti-MYLK Antibody, clone 1J2U2, Rabbit Monoclonal, ,
Espèces réactives
human, rat
Application
western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
ML-7, powder,
Espèce(s)
human

Proteins

Référence du produit
Description
Espèce(s)
MLCK Protein, active, 10 µg, Active, N-terminal 6His-tagged, recombinant, human MLCK, amino acids 1425-1771, for use in Kinase Assays.,
Espèce(s)
human
MLCK (1425-1776), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human MYLK (2),
Espèce(s)
human
MISSION® esiRNA, targeting mouse Mylk,
Espèce(s)
mouse
MISSION® esiRNA, targeting human MYLK (1),
Espèce(s)
human