MAP3K8
mitogen-activated protein kinase kinase kinase 8
Synonymes:
COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT
Espèce(s):
Human MAP3K8 (1326), Mouse Map3k8 (26410), Rat Map3k8 (116596), naked mole-rat Map3k8 (101710286), cow MAP3K8 (535622), Zebrafish map3k8 (563727), chicken MAP3K8 (420479), dog MAP3K8 (487085), domestic cat MAP3K8 (101090624), Horse MAP3K8 (100063602) ...Plus
ID UniProtKB:
ID du gène:
- Human(1326) Summary: This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
- Mouse(26410) mitogen-activated protein kinase kinase kinase 8
- Rat(116596) mitogen-activated protein kinase kinase kinase 8
- naked mole-rat(101710286) mitogen-activated protein kinase kinase kinase 8
- cow(535622) mitogen-activated protein kinase kinase kinase 8
- Zebrafish(563727) mitogen-activated protein kinase kinase kinase 8
- chicken(420479) mitogen-activated protein kinase kinase kinase 8
- dog(487085) mitogen-activated protein kinase kinase kinase 8
- domestic cat(101090624) mitogen-activated protein kinase kinase kinase 8
- Horse(100063602) mitogen-activated protein kinase kinase kinase 8
- sheep(101117094) mitogen-activated protein kinase kinase kinase 8
- Domestic Rabbit(100355566) mitogen-activated protein kinase kinase kinase 8
- domestic guinea pig(100725834) mitogen-activated protein kinase kinase kinase 8
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Antibodies
Numéro du produit
Description
Espèces réactives
Application
Anti-MAP3K8 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-MAP3K8 (pSer400) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
immunohistochemistry
Anti-MAP3K8 Antibody, clone 1D11 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human, mouse, rat
Application
affinity binding assay
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-MAP3K8 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
ANTI-COT (MAP3K8/MEKK8)(C-TERMINAL) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Cell Lines
Numéro du produit
Description
Espèce(s)
Proteins
Numéro du produit
Description
Espèce(s)
Cot1 Protein, active, 10 µg, Active, N-terminal 6His-tagged recombinant human Cot1, amino acids 30-397. For use in Kinase Assays.,
Espèce(s)
human
Cot active mouse, recombinant, expressed in baculovirus infected Sf9 cells, ≥50% (SDS-PAGE),
Espèce(s)
mouse