JAK1
Janus kinase 1
Synonymes:
JAK1A, JAK1B, JTK3
Espèce(s):
Human JAK1 (3716), Mouse Jak1 (16451), Rat Jak1 (84598), naked mole-rat Jak1 (101710283), domestic guinea pig Jak1 (100726895), Domestic Rabbit JAK1 (100352594), sheep JAK1 (101110716), domestic cat JAK1 (101084377), Horse JAK1 (100054008), cow JAK1 (537201) ...Plus
ID UniProtKB:
ID du gène:
- Human(3716) Summary: Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008]
- Mouse(16451) Janus kinase 1
- Rat(84598) Janus kinase 1
- naked mole-rat(101710283) Janus kinase 1
- domestic guinea pig(100726895) Janus kinase 1
- Domestic Rabbit(100352594) Janus kinase 1
- sheep(101110716) Janus kinase 1
- domestic cat(101084377) Janus kinase 1
- Horse(100054008) Janus kinase 1
- cow(537201) Janus kinase 1
- dog(442952) Janus kinase 1
- Zebrafish(30280) Janus kinase 1
- chicken(395681) Janus kinase 1
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ELISA
Référence du produit
Description
Espèce(s)
Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-JAK1 Antibody, clone 7Q1B2, Rabbit Monoclonal, ,
Espèces réactives
human, rat
Application
immunohistochemistry
western blot
western blot
Anti-JAK1 Antibody, serum, Upstate®,
Espèces réactives
hamster, human, mouse, rabbit, rat
Application
immunoprecipitation (IP)
western blot
western blot
Anti-phospho-JAK1 (pTyr1022) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-JAK1 (pTyr1022) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-phospho-JAK1 (Tyr1022/1023), from rabbit, purified by affinity chromatography,
Espèces réactives
bovine, canine, human, mouse, porcine, rat, rhesus macaque
Application
dot blot
western blot
western blot
Proteins
Référence du produit
Description
Espèce(s)
JAK1 Protein, active, 10 µg, Active, N-terminal GST-tagged, recombinant, human JAK1, amino acids 866-end, expressed by baculovirus in Sf21 insect cells. Activated in vitro by auto-phosphorylation. For use in Kinase Assays.,
Espèce(s)
human
Jak1 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE),
Espèce(s)
human