INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
Synonymes:
SHIP, SHIP-1, SHIP1, SIP-145, hp51CN
Espèce(s):
Human INPP5D (3635), Mouse Inpp5d (16331), Rat Inpp5d (54259), chicken INPP5D (424745), Zebrafish inpp5d (559103), naked mole-rat Inpp5d (101711777), domestic guinea pig Inpp5d (100722743), sheep INPP5D (101112941), Horse INPP5D (100064896), cow INPP5D (507329) ...Plus
ID UniProtKB:
ID du gène:
- Human(3635) Summary: This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
- Mouse(16331) inositol polyphosphate-5-phosphatase D
- Rat(54259) inositol polyphosphate-5-phosphatase D
- chicken(424745) inositol polyphosphate-5-phosphatase, 145kDa
- Zebrafish(559103) inositol polyphosphate-5-phosphatase, 145kDa
- naked mole-rat(101711777) inositol polyphosphate-5-phosphatase, 145kDa
- domestic guinea pig(100722743) inositol polyphosphate-5-phosphatase, 145kDa
- sheep(101112941) inositol polyphosphate-5-phosphatase, 145kDa
- Horse(100064896) inositol polyphosphate-5-phosphatase, 145kDa
- cow(507329) inositol polyphosphate-5-phosphatase, 145kDa
- domestic cat(101100500) inositol polyphosphate-5-phosphatase, 145kDa
- dog(100688270) inositol polyphosphate-5-phosphatase, 145kDa
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-INPP5D antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-SHIP1 (pTyr1021) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-SHIP1 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-SHIP1 Antibody, from rabbit, purified by affinity chromatography,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Anti-SHIP1 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
western blot
western blot
esiRNA
Référence du produit
Description
Espèce(s)