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GABBR2

gamma-aminobutyric acid (GABA) B receptor, 2

Synonymes:
GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(9568) Summary: The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]
  • Mouse(242425) gamma-aminobutyric acid (GABA) B receptor, 2
  • Rat(83633) gamma-aminobutyric acid (GABA) B receptor 2
  • domestic guinea pig(100170764) gamma-aminobutyric acid (GABA) B receptor, 2
  • naked mole-rat(101719923) gamma-aminobutyric acid (GABA) B receptor, 2
  • Horse(100063963) gamma-aminobutyric acid (GABA) B receptor, 2
  • sheep(101103544) gamma-aminobutyric acid (GABA) B receptor, 2
  • Domestic Rabbit(100346845) gamma-aminobutyric acid (GABA) B receptor, 2
  • domestic cat(101093058) gamma-aminobutyric acid (GABA) B receptor, 2
  • cow(517040) gamma-aminobutyric acid (GABA) B receptor, 2
  • dog(481627) gamma-aminobutyric acid (GABA) B receptor, 2
  • Zebrafish(560267) gamma-aminobutyric acid (GABA) B receptor, 2
  • chicken(420979) gamma-aminobutyric acid (GABA) B receptor, 2

Custom & Knockdown Gene Products

Small Molecule - Agonist

Numéro du produit
Description
Espèce(s)
Baclofen, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
Baclofen, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Baclofen, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human
Baclofen, British Pharmacopoeia (BP) Reference Standard,
Espèce(s)
human
(±)-Baclofen, ≥98% (HPLC), solid,
Espèce(s)
human, rat

Small Molecule - Allosteric Modulator

Numéro du produit
Description
Espèce(s)
CGP-13501, ≥98% (HPLC), solid,
Espèce(s)
human

Small Molecule - Antagonist

Numéro du produit
Description
Espèce(s)
2-Hydroxysaclofen, ≥98% (TLC), solid,
Espèce(s)
human
Phaclofen, solid,
Espèce(s)
human
(±)-Baclofen, ≥98% (HPLC), solid,
Espèce(s)
human, rat
Saclofen, solid,
Espèce(s)
mouse, human, rat
γ-Aminobutyric acid, ≥99%,
Espèce(s)
human, rat

Antibodies

Numéro du produit
Description
Espèces réactives
Application
Anti GABBR2 Antibody, clone 23GB5500, Rabbit Monoclonal, clone 23GB5500, recombinant rabbit monoclonal, expressed in HEK293 cells,
Espèces réactives
human, rat
Application
western blot
Anti-GABA B Receptor R2 Antibody, serum, from guinea pig,
Espèces réactives
bovine, canine, chimpanzee, horse, human, mouse, rat, rhesus macaque, rhesus monkey
Application
immunohistochemistry
western blot
Anti-GABAB Receptor 2 antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Espèces réactives
rat
Application
western blot
Monoclonal Anti-Gaba-B Receptor 2 - Rpe antibody produced in mouse, clone S81-2, purified immunoglobulin,
Espèces réactives
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry

western blot
Anti-GABBR2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry

Small Molecule - Inhibitor

Numéro du produit
Description
Espèce(s)
NO-711 hydrochloride, ≥98% (HPLC),
Espèce(s)
human
(±)-Vigabatrin, ,
Espèce(s)
human

esiRNA

Numéro du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human GABBR2,
Espèce(s)
human