Accéder au contenu
MilliporeSigma

FGFR3

fibroblast growth factor receptor 3

Synonymes:
ACH, CD333, CEK2, HSFGFR3EX, JTK4
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(2261) Summary: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009]
  • Mouse(14184) fibroblast growth factor receptor 3
  • Rat(84489) fibroblast growth factor receptor 3
  • cow(281769) fibroblast growth factor receptor 3
  • Horse(100034114) fibroblast growth factor receptor 3
  • naked mole-rat(101711651) fibroblast growth factor receptor 3
  • domestic guinea pig(100732948) fibroblast growth factor receptor 3
  • Zebrafish(58129) fibroblast growth factor receptor 3
  • chicken(396515) fibroblast growth factor receptor 3
  • domestic cat(100141386) fibroblast growth factor receptor 3
  • dog(488808) fibroblast growth factor receptor 3
  • sheep(554324) fibroblast growth factor receptor 3
No matching products for small molecule - inhibitor. Please clear filter

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.