ERBB2
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Synonymes:
CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
Espèce(s):
Human ERBB2 (2064), Mouse Erbb2 (13866), Rat Erbb2 (24337), domestic guinea pig Erbb2 (100727657), naked mole-rat Erbb2 (101705227), Zebrafish erbb2 (386966), chicken ERBB2 (426130), dog ERBB2 (403883), domestic cat ERBB2 (751824), Horse ERBB2 (100054739) ...Plus
ID UniProtKB:
ID du gène:
- Human(2064) Summary: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
- Mouse(13866) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- Rat(24337) v-erb-b2 avian erythroblastic leukemia viral oncogene 2
- domestic guinea pig(100727657) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- naked mole-rat(101705227) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- Zebrafish(386966) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
- chicken(426130) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
- dog(403883) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- domestic cat(751824) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- Horse(100054739) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- cow(505709) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
- sheep(780519) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- Domestic Rabbit(100009554) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
ELISA
Antibodies
Numéro du produit
Description
Espèces réactives
Application
Anti-c-ErbB2/c-Neu (Ab-3) Mouse mAb (3B5), liquid, clone 3B5, Calbiochem®,
Espèces réactives
human, mouse
Application
Anti-HER2 antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM228, purified immunoglobulin,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Anti-c-ErbB2/c-Neu (Ab-4) Mouse mAb (7.16.4), liquid, clone 7.16.4, Calbiochem®,
Espèces réactives
human, rat
Application
Alpaca Anti-Her2, recombinant single domain Antibody, Recombinant Alpaca (VHH) Nano antibody,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-ERBB2 antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Cell Lines
Small Molecule - Inhibitor
Proteins
Numéro du produit
Description
Espèce(s)
ErbB2/HER2/CD340 human, recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE),
Espèce(s)
human