COMT
catechol-O-methyltransferase
Synonymes:
Espèce(s):
Human COMT (1312), Mouse Comt (12846), Rat Comt (24267), cow COMT (618278), domestic guinea pig Comt (100730509), domestic cat COMT (101097022), naked mole-rat Comt (101717730), chicken COMT (416783), Horse COMT (100146509), fruit fly comt (47091)
ID UniProtKB:
ID du gène:
- Human(1312) Summary: Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
- Mouse(12846) catechol-O-methyltransferase
- Rat(24267) catechol-O-methyltransferase
- cow(618278) catechol-O-methyltransferase
- domestic guinea pig(100730509) catechol-O-methyltransferase
- domestic cat(101097022) catechol-O-methyltransferase
- naked mole-rat(101717730) catechol-O-methyltransferase
- chicken(416783) catechol-O-methyltransferase
- Horse(100146509) catechol-O-methyltransferase
- fruit fly(47091) comatose
- dog(445450) catechol-O-methyltransferase
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-Catechol O-methyltransferase/COMT Antibody, from rabbit, purified by affinity chromatography,
Espèces réactives
bovine, horse, human, porcine, rhesus macaque
Application
immunohistochemistry
western blot
western blot
Anti-COMT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human, rat
Application
western blot
Anti-COMT antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
ELISA
western blot
western blot
Monoclonal Anti-COMT antibody produced in mouse, clone 1G4-1A1, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
western blot
western blot
Anti-COMT antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
western blot
Small Molecule - Inhibitor
esiRNA
Référence du produit
Description
Espèce(s)