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MilliporeSigma

Consistent, reliable, simple.

Improve your research with Strat-M® Transdermal Diffusion Membrane.

Strat-M® Transdermal Diffusion Membrane

Experience the unmatched predictability of Strat-M® membrane —  synthetic, non-animal-based model for transdermal diffusion testing that is predictive of diffusion in human skin without lot-to-lot variability, safety, or storage limitations. How does the Strat-M® membrane mimic human skin? Watch this animation to find out and learn how the Strat-M® membrane can enable formulation optimization.

Designed for transdermal diffusion and safety testing of:

  • Cosmetic Actives
  • Formulations
  • Personal Care Products
  • Active Pharmaceutical Ingredients (API)
  • Pesticides and Chemicals
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Download Our Brochure

BROAD CHEMICAL COMPATIBILITY

Pharmaceutical Work Flow

API Screening
⮟
Formulation Screening
⮟
Formulation Optimization 
⮟
Clinical Development 
⮟
Post-Clinical Manufacturing
⮟  
Post-Market Activites

Personal Care Work Flow

'Actives' Screening
⮟
Formulation & Development
⮟
Clinical Development 
⮟
Post-Market Manufacturing
Use of skin or synthetic skin models

We’ve engineered predictive performance into the structure and chemistry of the Strat-M® membrane. Looking at the pharmaceutical & personal care workflow, Strat-M® membrane can be used where biological models are traditionally used and is an appropriate model for screening compounds with diverse physiochemical properties.

Strat-M Graph

Sources - Human Cadaver Skin: International Journal of Pharmaceutics, 2006, vol 310, pg 31-36; Porcine Skin: International Journal of Pharmaceutics, 1999, vol 181, pg 255-263

STRAT-M® MEMBRANE CORRELATES BETTER TO HUMAN SKIN COMPARED WITH OTHER BIOLOGICAL MODELS

Many researchers are using animal skin as a surrogate for human skin in IVPT studies because human skin is either difficult to obtain or in many countries, it cannot be used for in vitro research. Pig, rat, or mouse skin are commonly used as surrogates for human skin.

Strat-M® membrane correlates better to human skin compared with some of these animal skin models. For acetylsalicylic acid (aspirin, an analgesic), high flux was measured through both human skin and Strat-M® membrane; however, flux was lower through porcine skin, indicating that Strat-M® membrane is a better match for human skin than animal skin models.

For more information about how Strat-M correlates to human skin vs other biological models, see our brochure.

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Strat-M Graph

STRAT-M® MEMBRANE CORRELATION DATA

Are you:

  • Testing active compounds for transdermal diffusion?
  • Optimizing your formulations?
  • Using enhancers?
  • Performing safety testing on your formulations?

Use our interactive Compound Correlation Tool to learn how well the Strat-M® membrane will work for your specific needs.

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Related Videos

Slide 1 of 2
Demo Video: Strat-M<sup>®</sup> Transdermal Diffusion Membrane Testing using a Logan Franz Diffusion Cell System
Demo Video: Strat-M® Transdermal Diffusion Membrane Testing using a Logan Franz Diffusion Cell System
Watch this step-by-step video and learn how to use the Strat-M® synthetic skin membrane using a Logan Franz Diffusion cell system.
Webinar: <i>In Vitro</i> Skin Models
Webinar: In Vitro Skin Models
Dr. Vivek Joshi discusses the use of in vitro skin models, such as Strat-M® membranes, in the development of topical and transdermal formulations.
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Related Product Resources

Strat-M® Membranes in Action: Predicting Transdermal Diffusion

We’ve compiled a sampling of peer-reviewed studies which cite Strat-M® membranes, detailing procedures for its use in skin diffusion testing.

References

1.
Pan T, Wang P, Aljuffali IA, Hung Y, Lin C, Fang J. 2014. Dermal toxicity elicited by phthalates: Evaluation of skin absorption, immunohistology, and functional proteomics. Food and Chemical Toxicology. 65105-114. https://doi.org/10.1016/j.fct.2013.12.033
2.
Uchida T, Kadhum WR, Kanai S, Todo H, Oshizaka T, Sugibayashi K. 2015. Prediction of skin permeation by chemical compounds using the artificial membrane, Strat-M™. European Journal of Pharmaceutical Sciences. 67113-118. https://doi.org/10.1016/j.ejps.2014.11.002
3.
Flaten GE, Palac Z, Engesland A, Filipović-Grčić J, Vanić Ž, Škalko-Basneta1 N. 2015. In vitro skin models as a tool in optimization of drug formulation. European Journal of Pharmaceutical Sciences. 7510-24. https://doi.org/10.1016/j.ejps.2015.02.018
4.
Li J, Lee IW, Shin GH, Chen X, Park HJ. 2015. Curcumin-Eudragit® E PO solid dispersion: A simple and potent method to solve the problems of curcumin. European Journal of Pharmaceutics and Biopharmaceutics. 94322-332. https://doi.org/10.1016/j.ejpb.2015.06.002
5.
Lee W, Shen S, Aljuffali IA, Li Y, Fang J. 2014. Impact of Different Vehicles for Laser-Assisted Drug Permeation via Skin: Full-Surface versus Fractional Ablation. Pharm Res. 31(2):382-393. https://doi.org/10.1007/s11095-013-1167-4
6.
Kim JH, Ko JA, Kim JT, Cha DS, Cho JH, Park HJ, Shin GH. 2014. Preparation of a Capsaicin-Loaded Nanoemulsion for Improving Skin Penetration. J. Agric. Food Chem.. 62(3):725-732. https://doi.org/10.1021/jf404220n
7.
Beriro DJ, Cave MR, Wragg J, Thomas R, Wills G, Evans F. 2016. A review of the current state of the art of physiologically-based tests for measuring human dermal in vitro bioavailability of polycyclic aromatic hydrocarbons (PAH) in soil. Journal of Hazardous Materials. 305240-259. https://doi.org/10.1016/j.jhazmat.2015.11.010
8.
Nallagundla S, Patnala S, Kanfer I. 2014. Comparison of In Vitro Release Rates of Acyclovir from Cream Formulations Using Vertical Diffusion Cells. AAPS PharmSciTech. 15(4):994-999. https://doi.org/10.1208/s12249-014-0130-y
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