Family of Single-Use Mixing Systems
Perfected for the Conjugation Step
Mobius® ADC Reactors, Perfected for Bioconjugation of Antibody Drug Conjugates
The Mobius® ADC Reactor is a single-use mixing systems family, specifically designed for the key conjugation step to manufacture Antibody Drug Conjugates (ADCs). Offering scalability from 4 L to 500 L, this dedicated solution brings all the benefits from using single-use to the conjugation step. These include achieving faster turnaround times, avoiding cross-contamination risks, cleaning procedures and validation, while maintaining high product quality with no compromise on process continuity and operator safety.
Antibody-drug conjugates (ADCs) combine the specificity of monoclonal antibodies (mAbs) with the potency of cytotoxic drugs. The mAb targets a specific surface antigen on cancer cells, delivering a powerful small molecule payload directly to the tumor with high precision. The development and approval of ADCs are accelerating, making them an increasingly significant class of drugs in biopharmaceutical pipelines.
Tailored Design for Conjugation Challenges
From late development phase to manufacturing
- Linear scalability to accommodate varying batch sizes across three reactor sizes (10 L, 100 L, 500 L), from development scale to large-scale manufacturing.
- Conjugation reaction consistency scaling up or down and similar user-experience and training requirements.
All the benefits of single-use applied to conjugation
- Uncompromised quality with a selection of single-use product-contact components with proven compatibility and resistance to solvents such as DMAc and DMSO, ensuring product quality.
- Supply chain safety thanks to damage-resistant Ultimus® Film, with superior strength and leak resistance, ensuring improved bag integrity.
- Compared to stainless steel or glass reactors, single-use decreases implementation time and cost in production due to elimination of cross-contamination concerns and cleaning programs. Contribution to toxic waste streams during the cleaning process is also reduced.
Designed with the requirements of conjugation in mind
- Addition ports enable tailored material handling and precision, minimizing splashing and foaming during critical component addition.
- Uncompromised safety for a step involving use of highly potent pharmaceutical ingredients, with a bag made of robust components and film.
Related Product Categories
- Data Sheet: Mobius® ADC Reactor
A scalable family of single-use mixers perfected for bioconjugation.
- Article: Mobius® ADC Reactor Components Chemical Compatibility
It is important to evaluate the compatibility of the single-use components of an equipment dedicated to conjugation such as the Mobius® ADC reactor.
- Technical Brief: Mobius® ADC Reactor for Conjugation
The Mobius® ADC Reactor is designed to meet the precise demands of bioconjugation.
- Infographic: Single-use benefits for ADC manufacturing
The Mobius® ADC Reactor allows for flexible manufacturing that reduces risk and waste for maximum efficiency.
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