Membrane Chromatography

Our Natrix^® chromatography membrane technology provides a new level of downstream productivity and versatility. The macroporous structure, combined with high functional group density, enables high load capacity and excellent impurity removal at ultra-fast flow rates. With great performance in a single-use and scalable format, our innovative Natrix^® products improve process economics and facility utilization. 

• Natrix^® Q Chromatography Membrane
• Related resources

Natrix^® Q chromatography membrane

A high-capacity, high-throughput strong anion exchange membrane chromatography device designed for biomolecule purification, Natrix^® Q chromatography membrane is a porous polyacrylamide hydrogel containing a high density of pendant quaternary ammonium (Q) binding groups directly polymerized within an inert, macroporous membrane scaffold. The interconnected pore structure and high functional group density enables fast flow rates with impressive throughput to extremely high loads while maintaining excellent impurity removal across a wide range of buffer conditions. Natrix^® Q delivers improvements in productivity, flexibility, economic utility, and process robustness for any bioprocess design.

 

Related Product Resources

• Guide: Chromatography Product Selection Guide

  Protein A Affinity Chromatography Options

• Guide: Biochromatography Portfolio Guide

  Bulk Resin, Membranes and Prepacked Columns

• Guide: Natrix^® Q Chromatography Membrane

  With a revolutionary three-dimensional macroporous hydrogel structure that provides a high density of binding sites and rapid mass transfer, Natrix^® membranes deliver binding capacity that exceeds resin-based columns with fast flow rates.

• Guide: Natrix^® Q Chromatography Membrane Best Practices Guide

  With an innovative macroporous hydrogel structure that provides a high density of binding sites and rapid mass transfer, Natrix^® Q anion exchange (AEX) chromatography membranes deliver higher binding capacities than resin-based columns at fast flow rates typical of traditional membrane adsorbers.

• Data Sheet: Natrix^® Q Chromatography Membrane - For single-use, scalable purification

  Natrix^® chromatography membrane is a high capacity, high throughput strong anion exchange device designed to purify biomolecules.

• Application Note: Comparison of process-related impurity clearance for membrane adsorbers and resin-based chromatography technologies

  Strong anion exchange (AEX) chromatography has become an industry standard in polishing steps for monoclonal antibody (MAb) purification.

• Application Note: Robust, Load Independent Viral Clearance in Monoclonal Antibody Purification with Natrix^® Q Chromatography Membrane

  Anion exchange chromatography is an important flowthrough polishing step for viral clearance of monoclonal antibodies (mAbs).

• Brochure: What's Next: Exploring the Future of Bioprocessing Together

  Respondents viewed intensified technologies as mostly single use at the clinical-stage and as mostly hybrid at the commercial scale.

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Related Webinars

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Webinar: High Productivity Membrane Chromatography: Enabling the Next Generation Bioprocessing Paradigm 

Advantages of a fully single-use membrane-based purification process as well as high capacity flow through polishing with an inventive membrane absorber.

Webinar: Downstream Process Intensification for Virus Purification Using Membrane Chromatography

Improve virus purification yield, productivity & manufacturing flexibility while reducing costs via process intensification using membrane chromatography. 

Webinar: Membrane Chromatography Solutions for Single-Use, Intensified mAb Purification 

Learn the benefits of a novel Protein A affinity membrane, used as a high productivity, truly single-use chromatography platform for intensified mAb purification.