- Extracellular signal regulated kinase 5 and inflammasome in progression of mesothelioma.
Extracellular signal regulated kinase 5 and inflammasome in progression of mesothelioma.
Oncotarget (2018-02-09)
Joyce K Thompson, Anurag Shukla, Alan L Leggett, Phillip B Munson, Jill M Miller, Maximilian B MacPherson, Stacie L Beuschel, Harvey I Pass, Arti Shukla
PMID29416614
ABSTRACT
Malignant mesothelioma is an aggressive cancer in desperate need of treatment. We have previously shown that extracellular signaling regulated kinase 5 (ERK5) plays an important role in mesothelioma pathogenesis using ERK5 silenced human mesothelioma cells exhibiting significantly reduced tumor growth in immunocompromised mice. Here, we used a specific ERK 5 inhibitor, XMD8-92 in various
MATERIALS