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Computational Design and Synthesis of Novel Fluoro-Analogs of Combretastatins A-4 and A-1.

Computational Design and Synthesis of Novel Fluoro-Analogs of Combretastatins A-4 and A-1.

Journal of fluorine chemistry (2018-01-10)

Yao Zong, Christie Shea, Katherine Maffucci, Iwao Ojima

ABSTRACT

Combretastatin A-1 (CA-1) and combretastatin A-4 (CA-4) isolated from the African bush willow

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

4-(Difluoromethoxy)benzaldehyde, 95%

Sigma-Aldrich

3-fluoro-4-(trifluoromethoxy)benzaldehyde, Aldrich^CPR