- FGF5 is expressed in melanoma and enhances malignancy
FGF5 is expressed in melanoma and enhances malignancy
Oncotarget (2017-11-21)
Sara Ghassemi, Katharina Vejdovszky, Emine Sahin, Lukas Ratzinger, Karin Schelch, Thomas Mohr, Barbara Peter-Vörösmarty, Jelena Brankovic, Andreas Lackner, Alexandra Leopoldi, Diana Meindl, Christine Pirker, Balazs Hegedus, Brigitte Marian, Klaus Holzmann, Bettina Grasl-Kraupp, Petra Heffeter, Walter Berger, Michael Grusch
PMID29152117
ABSTRACT
Although FGF5 mRNA was previously found expressed in some melanoma cell lines in contrast to normal human melanocytes, neither its contribution to melanoma growth nor its expression in melanoma tissue has been investigated. Here we demonstrate that ectopic overexpression of FGF5 in human melanoma cells with low endogenous FGF5 expression increased clonogenicity and invasion but not short-term growth
MATERIALS