- Fascin promotes migration and invasion and is a prognostic marker for oral squamous cell carcinoma.
Fascin promotes migration and invasion and is a prognostic marker for oral squamous cell carcinoma.
Oncotarget (2017-11-02)
Priscila Campioni Rodrigues, Iris Sawazaki-Calone, Carine Ervolino de Oliveira, Carolina Carneiro Soares Macedo, Mauricio Rocha Dourado, Nilva K Cervigne, Marcia Costa Miguel, Andreia Ferreira do Carmo, Daniel W Lambert, Edgard Graner, Sabrina Daniela da Silva, Moulay A Alaoui-Jamali, Adriana Franco Paes Leme, Tuula A Salo, Ricardo D Coletta
PMID29088820
ABSTRACT
Oral squamous cell carcinoma (OSCC) prognosis is related to clinical stage and histological grade. However, this stratification needs to be refined. We conducted a comparative proteome study in microdissected samples from normal oral mucosa and OSCC to identify biomarkers for malignancy. Fascin and plectin were identified as differently expressed and both are implicated in several malignancies, but the clinical impacts of aberrant fascin and plectin expression in OSCCs remains largely unknown. Immunohistochemistry and real-time quantitative PCR were carried out in
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