- Cloning and expression pattern of the human NDRG3 gene.
Cloning and expression pattern of the human NDRG3 gene.
Biochimica et biophysica acta (2001-06-19)
W Zhao, R Tang, Y Huang, W Wang, Z Zhou, S Gu, J Dai, K Ying, Y Xie, Y Mao
PMID11406283
ABSTRACT
We report the cloning and expression pattern of a novel N-myc downstream-regulated gene 3 (NDRG3), located on human chromosome 20q11.21-11.23. The NDRG3 cDNA is 2588 base pair in length, encoding a 363 amino acid polypeptide highly related to mouse Ndr3 protein. Northern blot reveals that NDRG3 is highly expressed in testis, prostate and ovary. By in situ hybridization, the NDRG3 mRNA was localized to the outer layers of seminiferous epithelium, indicating that it may play a role in spermatogenesis.