- Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans.
Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans.
Antimicrobial agents and chemotherapy (1997-06-01)
M E Klepser, E J Wolfe, R N Jones, C H Nightingale, M A Pfaller
PMID9174207
ABSTRACT
Time-kill curves were determined for three isolates of Candida albicans tested against fluconazole and amphotericin B at multiples of the MIC. Fluconazole produced fungistatic activity, with concentration-related growth effects observed over a narrow range of concentrations. Amphotericin B exhibited fungicidal activity, with enhancement of activity over a broader range of concentrations.
MATERIALS