- First synthesis of an amythiamicin pyridine cluster.
First synthesis of an amythiamicin pyridine cluster.
Chemical communications (Cambridge, England) (2004-01-23)
Mark C Bagley, James W Dale, Robert L Jenkins, Justin Bower
PMID14737352
ABSTRACT
The pyridine-containing central domain of the amythiamicin group of thiopeptide antibiotics is prepared in protected form in 9 steps, 93%ee and 18% overall yield from (S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]thiazole-4-carboxylic acid by Michael addition-cyclodehydration of a 2-(2-thiazolyl)enamine and 1-(2-thiazolyl)propynone.