- From histamine to imidazolylalkyl-sulfonamides: the design of a novel series of histamine H3-receptor antagonists.
From histamine to imidazolylalkyl-sulfonamides: the design of a novel series of histamine H3-receptor antagonists.
Bioorganic & medicinal chemistry letters (1999-07-16)
M J Tozer, E A Harper, S B Kalindjian, M J Pether, N P Shankley, G F Watt
PMID10406649
ABSTRACT
Histamine was converted to a selective histamine H3-receptor antagonist by capping the primary amine with 2-naphthalenesulfonyl chloride. Higher receptor affinity and lower variability in the data from the various bioassays were achieved with the 2-naphthalensulfonamides of histamine homologues.
MATERIALS