Skip to Content
MilliporeSigma
  • Synthesis and biological evaluation of new 5-fluorouracil-substituted ampelopsin derivatives.

Synthesis and biological evaluation of new 5-fluorouracil-substituted ampelopsin derivatives.

Molecules (Basel, Switzerland) (2010-04-30)
Wei-Ming Zhou, Rong-Rong He, Jian-Tao Ye, Na Zhang, De-Yu Liu
PMID20428031
ABSTRACT

This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, 1H-NMR, 13C-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated using the MTT assay, and the results showed that the two new compounds were more effective than reference drugs such as ampelopsin and verapamil.