- The control of impurities in amitriptyline hydrochloride using a reversed-phase hybrid stationary phase.
The control of impurities in amitriptyline hydrochloride using a reversed-phase hybrid stationary phase.
Pharmeuropa scientific notes (2007-08-11)
S P Dixon, A Lodi, J H M Miller, G G Skellern
PMID17687889
ABSTRACT
An isocratic reversed-phase liquid chromatographic method is described using a hybrid column for the control of synthetic impurities potentially found in amitriptyline hydrochloride. The method has been validated and is capable of controlling impurities to 0.1 per cent.
MATERIALS
Product Number
Brand
Product Description
Dibenzosuberone, European Pharmacopoeia (EP) Reference Standard