- Complexation of Hypocrellin A with Al3+ in water solution and the photodynamic therapy study.
Complexation of Hypocrellin A with Al3+ in water solution and the photodynamic therapy study.
Bioorganic & medicinal chemistry letters (2013-02-16)
Fei Ma, Heyong Huang, Xuefeng Ge, Xiaodi Yang, Chao Yang, Lina Han, Jiahong Zhou, Lin Zhou
PMID23411082
ABSTRACT
The complex of Hypocrellin A with Al(3+) is prepared in water solution by a facile method. The water-solubility and stability of complexes are improved. Irradiation of Al(3+)-HA complex results in higher efficient generation of singlet oxygen ((1)O2) and photocleavage ability to CT DNA than HA. In vitro studies have illustrated that the Al(3+)-HA complex has anti-cancer activity.