Skip to Content
MilliporeSigma

Lipase catalysed synthesis of optically enriched alpha-haloamides.

Bioorganic & medicinal chemistry (2001-05-30)
A Azim, S K Sharma, C E Olsen, V S Parmar
PMID11377191
ABSTRACT

An efficient lipase catalysed synthesis of optically enriched alpha-halogenated amides with concomitant optical enrichment of the starting alpha-haloesters is described. Candida antarctica lipase (CAL) was found to be a better catalyst over porcine pancreatic lipase (PPL) and Candida cylindracea lipase (CCL). The effect of different organic solvents was also studied.

MATERIALS
Product Number
Brand
Product Description
95251
Supelco
Diisopropyl ether, analytical standard
296856
Sigma-Aldrich
Diisopropyl ether, anhydrous, 99%, contains either BHT or hydroquinone as stabilizer
185302
Sigma-Aldrich
Diisopropyl ether, ReagentPlus®, 99%, contains either BHT or hydroquinone as stabilizer
673803
Sigma-Aldrich
Diisopropyl ether, contains either BHT or hydroquinone as stabilizer, ACS reagent, ≥99.0%
38270
Sigma-Aldrich
Diisopropyl ether, puriss. p.a., ≥98.5% (GC)
398276
Sigma-Aldrich
Diisopropyl ether, contains either BHT or hydroquinone as stabilizer, ACS reagent, ≥99.0%