- Practical biocatalytic desymmetrization of meso-N-heterocyclic dicarboxamides and their application in the construction of aza-sugar containing nucleoside analogs.
Practical biocatalytic desymmetrization of meso-N-heterocyclic dicarboxamides and their application in the construction of aza-sugar containing nucleoside analogs.
Chemical communications (Cambridge, England) (2012-02-11)
Peng Chen, Ming Gao, De-Xian Wang, Liang Zhao, Mei-Xiang Wang
PMID22322323
ABSTRACT
Amidase-catalyzed desymmetrization of meso-N-heterocyclic dicarboxamides under very mild conditions provided a highly efficient and practical method for the preparation of enantiomerically pure carbamoyl-substituted heterocyclic amino acids that were unique and versatile platforms for the construction of both antipodes of aza-sugar containing nucleoside analogs.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Amidase from Pseudomonas aeruginosa, recombinant, expressed in E. coli, buffered aqueous glycerol solution, hydroxamate transferase ≥200 units/mg protein (biuret)