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Efficient and highly aldehyde selective Wacker oxidation.

Organic letters (2012-06-15)
Peili Teo, Zachary K Wickens, Guangbin Dong, Robert H Grubbs
PMID22694293
ABSTRACT

A method for efficient and aldehyde-selective Wacker oxidation of aryl-substituted olefins using PdCl(2)(MeCN)(2), 1,4-benzoquinone, and t-BuOH in air is described. Up to a 96% yield of aldehyde can be obtained, and up to 99% selectivity can be achieved with styrene-related substrates.

MATERIALS
Product Number
Brand
Product Description
8.02410
Sigma-Aldrich
p-Benzoquinone, for synthesis