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  • Natural product inhibitors of protein-protein interactions mediated by Src-family SH2 domains.

Natural product inhibitors of protein-protein interactions mediated by Src-family SH2 domains.

Bioorganic & medicinal chemistry letters (2009-05-12)
Bianca Sperl, Markus H J Seifert, Thorsten Berg
ABSTRACT

In this Letter, we report the natural products salvianolic acid A, salvianolic acid B, and caftaric acid as inhibitors of the protein-protein interactions mediated by the SH2 domains of the Src-family kinases Src and Lck, two established disease targets. Moreover, we propose a binding mode for the inhibitors based on molecular modeling, which will facilitate chemical optimization efforts of these important lead structures for drug discovery.

MATERIALS
Product Number
Brand
Product Description

Chlorogenic acid, primary reference standard
Sigma-Aldrich
Rosmarinic acid, 96%
Sigma-Aldrich
Chlorogenic acid, ≥95% (titration)