- 4-hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent.
4-hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent.
Bioorganic & medicinal chemistry letters (2005-10-26)
Tadigoppula Narender, Anju Puri, Shweta, Tanvir Khaliq, Rashmi Saxena, Geetika Bhatia, Ramesh Chandra
PMID16246556
ABSTRACT
Trigonella foenum-graecum, commonly known as fenugreek, is an annual herbaceous plant. From the seeds of T. foenum-graecum an unusual amino acid, 4-hydroxyisoleucine 5, has been isolated, which significantly decreased the plasma triglyceride levels by 33% (P<0.002), total cholesterol (TC) by 22% (P<0.02), and free fatty acids by 14%, accompanied by an increase in HDL-C/TC ratio by 39% in the dyslipidemic hamster model.
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