SRP6561

Cathepsin K Active human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• Synonym(s): CTSK, CTSO, CTSO3
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in E. coli
• Assay: ≥90% (SDS-PAGE)
• form: liquid
• mol wt: 23.5 kDa (115-329 aa)
• packaging: pkg of 5 μg; pkg of 50 μg
• concentration: 0.5 mg/mL
• technique(s): activity assay: suitable
• suitability: suitable for molecular biology
• UniProt accession no.: P43235
• application(s): life science and biopharma
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... CTSK(1513)

Description

General description

Cathepsin K is expressed as procathepsin K, which is the inactive proenzyme of cathepsin K. Cathepsin K is a lysosomal cysteine protease and part of the papain cysteine protease family. It is expressed in osteoclasts. The gene encoding this protein is localized on human chromosome 1q21.

Biochem/physiol Actions

Cathepsin K has a role in bone resorption and remodeling. It has a triple helical collagen hydrolase activity. Mutations in the gene encoding this protein have been linked to pycnodysostosis.

Physical form

0.5 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable