Skip to Content
MilliporeSigma
All Photos(1)

Documents

SML3302

Sigma-Aldrich

SNI-1

≥98% (HPLC)

Synonym(s):

1-(3,4-Dihydroxy-phenyl)-2-(1-p-tolyl-1H-tetrazol-5-ylsulfanyl)-ethanone

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C16H14N4O3S
CAS Number:
634169-12-3
Molecular Weight:
342.37
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1=CC=C(C=C1)N2C(SCC(C3=CC(O)=C(C=C3)O)=O)=NN=N2

Biochem/physiol Actions

SNI-1 is an inhibitor of CARP-1(CCAR1)-NEMO (NF-κB essential modulator) interaction that binds to CARP-1. SNI-1 inhibits chemotherapy-dependent canonical NF-κB signaling and attenuates secretion of the pro-inflammatory cytokines TNFα, IL-1β, and IL-8. It potentiates chemotherapeutic effects of DNA damaging agents such as Cisplatin and Adriamycin (doxorubicin) in several cancer cell lines including human triple-negative breast cancer (TNBC).

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Jaganathan Venkatesh et al.
The Journal of biological chemistry, 295(11), 3532-3552 (2020-02-07)
NF-κB is a pro-inflammatory transcription factor that critically regulates immune responses and other distinct cellular pathways. However, many NF-κB-mediated pathways for cell survival and apoptosis signaling in cancer remain to be elucidated. Cell cycle and apoptosis regulatory protein 1 (CARP-1

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service