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SAB3500666

Sigma-Aldrich

Anti-TRMT12 antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

mol wt

49 kDa

species reactivity

human, mouse

concentration

1 mg/mL

technique(s)

ELISA: suitable
immunocytochemistry: suitable
western blot: suitable

UniProt accession no.

Q53H54

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TRMT12(55039)

Related Categories

General description

TRMT12 (tRNA methyltransferase 12 homolog) gene is localized to human chromosome 8q24, and is a homolog of yeast gene coding for a tRNA methyltransferase.

Immunogen

Antibody was raised against a 19 amino acid peptide near the amino terminus of human TYW2.

Biochem/physiol Actions

TRMT12 (tRNA methyltransferase 12 homolog) gene is amplified and over-expressed in breast cancer. This enzyme is responsible for catalyzing the third step in wybutosine biosynthetic pathway. In cancer, up-regulation of this gene leads to disruption in SMG1 protein function, which is a part of nonsense mediated decay pathway (NMD). Thus, it might contribute to the escape of damaged DNA from checkpoints.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500666.

Physical form

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.

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Description
Pricing

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer.
Rodriguez V et al
Genes Chromosomes Cancer, 46(7), 694-707 (2007)
TRMT12 overexpression in cancer cells affects the cell cycle and the nonsense mediated decay pathways by regulating the SMG-1 kinase, a member of the PIKK family of kinases.
Rodriguez V et al
Cancer Research, 69(9), 2486-2486 (2009)

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