H8885

Hydroxyzine dihydrochloride

≥97%

• Empirical Formula (Hill Notation): C₂₁H₂₇ClN₂O₂ · 2HCl
• CAS Number: 2192-20-3
• Molecular Weight: 447.83
• EC Number: 218-586-3
• MDL number: MFCD00058200
• UNSPSC Code: 12161501
• PubChem Substance ID: 24895830
• NACRES: NA.77

Properties

• Assay: ≥97%
• form: powder
• solubility: H₂O: soluble; alcohol: soluble; chloroform: soluble
• SMILES string: Cl[H].Cl[H].OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3
• InChI: 1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H
• InChI key: ANOMHKZSQFYSBR-UHFFFAOYSA-N
• Gene Information: human ... HRH1(3269)

Description

General description

Hydroxyzine dihydrochloride (HDH) is the first-generation antihistamine, that belongs to the piperazine class, an H1 receptor antagonist.

Application

Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.

Biochem/physiol Actions

Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Warning
• Hazard Statements: H302,H336,H361d
• Precautionary Statements: P202 - P261 - P264 - P271 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2 - STOT SE 3
• Target Organs: Central nervous system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves