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75256

Supelco

Synephrine

analytical standard

Synonym(s):

1-(4-Hydroxyphenyl)-2-methylaminoethanol, 4-Hydroxy-α-(methylaminomethyl)benzyl alcohol

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About This Item

Empirical Formula (Hill Notation):
C9H13NO2
CAS Number:
94-07-5
Molecular Weight:
167.21
EC Number:
202-300-9
MDL number:
MFCD00002370
UNSPSC Code:
85151701
PubChem Substance ID:
329766291
NACRES:
NA.24

grade

analytical standard

Assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤12.0% water (Karl Fischer)

application(s)

food and beverages

format

neat

storage temp.

2-8°C

InChI

1S/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3

InChI key

YRCWQPVGYLYSOX-UHFFFAOYSA-N

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General description

Synephrine is a sympathomimetic amine from the plant Citrus aurantium and is identified as a major active component of dietary supplements.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Synephrine may be used as a reference standard for the determination of synephrine in dietary supplements using high-performance liquid chromatography with acidic potassium permanganate chemiluminescence detection.

Analysis Note

identification (GC-MS): identity conforms

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH6804
BCCH4739
BCCG9038
BCCG7213
BCCG4406

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Determination of synephrine in weight-loss products using high performance liquid chromatography with acidic potassium permanganate chemiluminescence detection.
Slezak T, et al.
Analytica Chimica Acta, 593(1), 98-102 (2007)
Ischemic stroke associated with use of an ephedra-free dietary supplement containing synephrine.
Bouchard CN, et al.
Mayo Clinic Proceedings. Mayo Clinic, 80(4), 541-545 (2005)
Sidney J Stohs et al.
Phytotherapy research : PTR, 25(10), 1421-1428 (2011-04-12)
Citrus aurantium (bitter orange) extract and its principal protoalkaloidal constituent p-synephrine are widely used in weight loss and weight management as well as in sports performance products. However, questions are raised frequently regarding the safety of these ingredients. The potential
S Haaz et al.
Obesity reviews : an official journal of the International Association for the Study of Obesity, 7(1), 79-88 (2006-01-27)
Obesity is a major health problem facing the developed and developing world. Efforts by individuals, health professionals, educators, and policy makers to combat the escalating trend of growing obesity prevalence have been multifaceted and mixed in outcome. Various dietary supplements
John E Thomas et al.
Texas Heart Institute journal, 36(6), 586-590 (2010-01-14)
Billions of dollars are spent annually in the United States in the largely unregulated market of dietary supplements. Many of these supplements are marketed as weight-loss and athletic-performance-enhancement products. The association of various ephedra-containing products with adverse cardiovascular events has
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