SPTBN2
spectrin, beta, non-erythrocytic 2
Synonyms:
GTRAP41, SCA5, SCAR14
Species:
Human SPTBN2 (6712), Mouse Sptbn2 (20743), Rat Sptbn2 (29211), sheep SPTBN2 (101106728), domestic guinea pig Sptbn2 (100731189), dog SPTBN2 (483706), Zebrafish sptbn2 (322068), cow SPTBN2 (100336865), naked mole-rat Sptbn2 (101714181), Domestic Rabbit SPTBN2 (100355265) ...More
UniProtKB ID:
Gene ID:
- Human(6712) Summary: Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009]
- Mouse(20743) spectrin beta, non-erythrocytic 2
- Rat(29211) spectrin, beta, non-erythrocytic 2
- sheep(101106728) spectrin, beta, non-erythrocytic 2
- domestic guinea pig(100731189) spectrin, beta, non-erythrocytic 2
- dog(483706) spectrin, beta, non-erythrocytic 2
- Zebrafish(322068) spectrin, beta, non-erythrocytic 2
- cow(100336865) spectrin, beta, non-erythrocytic 2
- naked mole-rat(101714181) spectrin, beta, non-erythrocytic 2
- Domestic Rabbit(100355265) spectrin, beta, non-erythrocytic 2
- domestic cat(101089045) spectrin, beta, non-erythrocytic 2
- cow(100336410) spectrin, beta, non-erythrocytic 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-SPTBN2 antibody produced in mouse, clone 4D9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-SPTBN2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-SPTBN2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-Spectrin antibody produced in rabbit, whole antiserum,
Species Reactivity
human
Application
western blot