RAP1GAP
RAP1 GTPase activating protein
Synonyms:
RAP1GA1, RAP1GAP1, RAP1GAPII, RAPGAP
Species:
Human RAP1GAP (5909), Mouse Rap1gap (110351), Rat Rap1gap (313644), Domestic Rabbit RAP1GAP (100340849), domestic cat RAP1GAP (101093787), chicken RAP1GAP (769475), naked mole-rat Rap1gap (101726267), Zebrafish rap1gap (100538309), sheep RAP1GAP (101104377), Zebrafish rap1gap (100144557) ...More
UniProtKB ID:
Gene ID:
- Human(5909) Summary: This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]
- Mouse(110351) Rap1 GTPase-activating protein
- Rat(313644) Rap1 GTPase-activating protein
- Domestic Rabbit(100340849) RAP1 GTPase activating protein
- domestic cat(101093787) RAP1 GTPase activating protein
- chicken(769475) RAP1 GTPase activating protein
- naked mole-rat(101726267) RAP1 GTPase activating protein
- Zebrafish(100538309) RAP1 GTPase activating protein
- sheep(101104377) RAP1 GTPase activating protein
- Zebrafish(100144557) RAP1 GTPase activating protein
- domestic guinea pig(100725658) RAP1 GTPase activating protein
- dog(487387) RAP1 GTPase activating protein
- cow(532839) RAP1 GTPase activating protein
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-RAP1GAP antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse
Application
immunohistochemistry
Monoclonal Anti-RAP1GA1 antibody produced in mouse, clone 3G11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
Anti-Rap1GAP Antibody, clone 8V9I6, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunofluorescence
western blot
western blot
esiRNA
Product Number
Description
Species