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PCSK2

proprotein convertase subtilisin/kexin type 2

Synonyms:
NEC 2, NEC-2, NEC2, PC2, SPC2
Species:
UniProtKB ID:
Gene ID:
  • Human(5126) Summary: This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
  • Mouse(18549) proprotein convertase subtilisin/kexin type 2
  • Rat(25121) proprotein convertase subtilisin/kexin type 2
  • Zebrafish(100004460) proprotein convertase subtilisin/kexin type 2
  • domestic cat(101098130) proprotein convertase subtilisin/kexin type 2
  • naked mole-rat(101710029) proprotein convertase subtilisin/kexin type 2
  • domestic guinea pig(100727607) proprotein convertase subtilisin/kexin type 2
  • chicken(395136) proprotein convertase subtilisin/kexin type 2
  • dog(485757) proprotein convertase subtilisin/kexin type 2
  • Domestic Rabbit(100358339) proprotein convertase subtilisin/kexin type 2
  • Horse(100050755) proprotein convertase subtilisin/kexin type 2
  • cow(281968) proprotein convertase subtilisin/kexin type 2

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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ELISA

Product Number
Description
Species
Human PCSK2 ELISA, for serum, plasma and cell culture supernatants,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PCSK2 antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse
Application
western blot
Anti-Prohormone Convertase PC2 Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human, mouse, porcine, rhesus macaque
Application
immunohistochemistry
western blot
Anti-PCSK2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Monoclonal Anti-PCSK2 antibody produced in mouse, clone 3H4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Pcsk2,
Species
mouse
MISSION® esiRNA, targeting human PCSK2,
Species
human