GSKIP
GSK3B interacting protein
Synonyms:
C14orf129
Species:
Human GSKIP (51527), Mouse Gskip (66787), Rat Gskip (362778), sheep GSKIP (101121297), Zebrafish gskip (406744), domestic guinea pig Gskip (100725078), domestic cat GSKIP (101082921), dog GSKIP (611079), naked mole-rat Gskip (101716184), cow GSKIP (616052)
UniProtKB ID:
Gene ID:
- Human(51527) Summary: This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
- Mouse(66787) GSK3B interacting protein
- Rat(362778) GSK3B interacting protein
- sheep(101121297) GSK3B interacting protein
- Zebrafish(406744) gsk3b interacting protein
- domestic guinea pig(100725078) GSK3B interacting protein
- domestic cat(101082921) GSK3B interacting protein
- dog(611079) GSK3B interacting protein
- naked mole-rat(101716184) GSK3B interacting protein
- cow(616052) GSK3B interacting protein
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