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Merck

Kinomics.

Current drug metabolism (2008-03-14)
Virendra S Gomase, Somnath Tagore
ABSTRACT

Kinomics is derived from the word kinome that is the kinase part of the proteome. Kinomics is a merger between genomics and proteomics. Defining the kinase complement of the human genome, the kinome, has provided an excellent starting point for understanding the scale of the problem. This approach combines the understanding of small molecules and targets, and thereby assists the researcher in finding new targets for existing molecules or understanding selectivity and poly-pharmacology of molecules in related targets. Deciphering the complex network of phosphorylation-based signaling is necessary for a thorough and therapeutically applicable understanding of the functioning of a cell in physiological and pathological states.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
MISSION® shRNA Mouse Gene Family Set, Lentiviral Particles, Kinases
Sigma-Aldrich
MISSION® shRNA Mouse Gene Family Set, Bacterial Glycerol Stock, Kinases
Sigma-Aldrich
MISSION® shRNA Human Gene Family Set, DNA, Kinases
Sigma-Aldrich
MISSION® shRNA Human Gene Family Set, Bacterial Glycerol Stock, Kinases
Sigma-Aldrich
MISSION® shRNA Human Gene Family Set, Lentiviral Particles, Kinases
Sigma-Aldrich
MISSION® shRNA Mouse Gene Family Set, DNA, Kinases