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SAB4500548

Sigma-Aldrich

Anti-Adrenergic Receptor α-2A antibody produced in rabbit

affinity isolated antibody

Synonym(s):

α-2 adrenergic receptor subtype C10, α-2A adrenergic receptor, α-2A adrenoceptor, α-2A adrenoreceptor, α-2AAR

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About This Item

MDL number:
MFCD01321639
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 48 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P08913

UniProt accession no.

P08913

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADRA2A(150)

General description

ADRA2A (α-2A adrenergic receptor gene) is located on human chromosome 10q25. It is expressed in the caudate nucleus.
Anti-Adrenergic Receptor α-2A Antibody detects endogenous levels of total Adrenergic Receptor α-2A protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Adrenergic Receptor alpha-2A.

Immunogen Range: 331-380

Biochem/physiol Actions

ADRA2A (α-2A adrenergic receptor gene) plays an important role in irritability, impulsivity, aggression and memory traits. Mutations in ADRA2A affects the liberation of insulin and glucose regulation. Variations in ADRA2A is linked with poor clinical prognostication. It participates in autism spectrum disorders (ASDs).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Abhishek Tripathi et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(13), E1659-E1668 (2015-03-17)
Recent evidence suggests that chemokine (C-X-C motif) receptor 4 (CXCR4) contributes to the regulation of blood pressure through interactions with α1-adrenergic receptors (ARs) in vascular smooth muscle. The underlying molecular mechanisms, however, are unknown. Using proximity ligation assays to visualize
Alpha2A adrenergic receptor genetic variation contributes to hyperglycemia after myocardial infarction
Adefurin A, et al.
International Journal of Cardiology, 215, 482-486 (2016)
Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans
Ramos E, et al.
Diabetologia, 54(4), 783-788 (2011)
Ute A Schwinghammer et al.
Cells, 9(2) (2020-02-23)
The noradrenergic system is proposed to play a prominent role in the pathogenesis of liver fibrosis. While α1- and β-adrenergic receptors (ARs) are suggested to be involved in a multitude of profibrogenic actions, little is known about α2-AR-mediated effects and
Association between the adrenergic alpha 2A receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects
Comings DE, et al.
Psychiatric Genetics, 10(1), 39-42 (2000)
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