SAB2500260

Anti-Complement Factor H antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-CFH, Anti-CFHL3, Anti-HF, Anti-HGNC:4883
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: goat
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• UniProt accession no.: P08603
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CFH(3075)

Description

General description

Complement factor H (CFH) codes for 20 complement-control protein modules (CCPs 1–20). It is expressed in the liver, mesangial cells, endothelial cells and fibroblasts. It is a membrane cofactor protein. The CFH gene is localized on human chromosome 1q31.3.

Immunogen

Peptide with sequence C-HLVPDRKKDQYK from the internal region of the protein sequence according to NP_000177.2.

Biochem/physiol Actions

Complement factor H (CFH) is a negative regulator of the alternative pathway. It suppresses spontaneous complement activation and its response on self surfaces. CFH possesses decay-accelerating activity and destabilizes the C3b amplification in the alternate complement pathway. It also has a role in C3b cleavage by its cofactor activity. The protein has been linked to various diseases like age-related macular degeneration, kidney disorder and C3 glomerulopathy. CFH might prevent complement activation in ischemic renal injury by binding to tubular epithelial cells.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable