- [Neutrophils and hyaluronians in carcinogenesis].
[Neutrophils and hyaluronians in carcinogenesis].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego (2013-07-26)
Marcin Tchórzewski, Adam Dziki, Henryk Tchórzewski
PMID23882925
ABSTRACT
Inflammatory processes involving polymorphonuclear leukocytes (PMNL) play an important role in cancer. PMNL can affect the formation and growth of the tumor. Cancer cells produce significant amounts of hyaluronans (HA), which pass into the extracellular space and are responsible for the inhibition of PMNL function through TLR4 receptor, and increase in the production of IL 10 the immunosuppressive cytokine as well as the other proinflammatory cytokines. HA supported the metastasis of cancer cells by binding to the CD44 receptor on endothelial cells. Increased PMNL--Lymphocyte ratio as a negative prognostic factor indicates also the important not defined role of PMNL in carcinogenesis.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Hyaluronic acid sodium salt from rooster comb, avian glycosaminoglycan polysaccharide
Sigma-Aldrich
Hyaluronic acid sodium salt from Streptococcus equi, bacterial glycosaminoglycan polysaccharide
Sigma-Aldrich
Hyaluronic acid sodium salt from Streptococcus zooepidemicus, bacterial glycosaminoglycan polysaccharide