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Key Documents

257M-1

Sigma-Aldrich

GCDFP-15 (23A3) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

23A3, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (257M-14)
vial of 0.5 mL concentrate (257M-15)
bottle of 1.0 mL predilute (257M-17)
vial of 1.0 mL concentrate (257M-16)
bottle of 7.0 mL predilute (257M-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

isotype

IgG2a

control

breast, breast carcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... PIP(5304)

General description

GCDFP-15 is a 15 kD glycoprotein which is localized in the apocrine metaplastic epithelium lining breast cysts and in apocrine glands in the axilla, vulva, eyelid, ear canal, and in salivary glands. Approximately 70% of breast carcinomas are labeled with antibody to GCDFP-15. Colorectal carcinomas, lung carcinoma, mesothelimas rarely stain with this antibody. Because of its specificity for breast carcinoma (up to 99%), this antibody is often used in a screening panel in the appropriate clinical situation, often for a woman with metastasis of unknown primary.

Quality


IVD
IVD
IVD
RUO

Linkage

GCDFP-15 Positive Control Slides, Product No. 257S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A H Ormsby et al.
Journal of the American Academy of Dermatology, 32(5 Pt 1), 711-716 (1995-05-01)
For accurate classification of cutaneous metastatic carcinoma, reliable tumor-specific immunohistochemical markers would be valuable. Our purpose was to analyze the sensitivity, specificity, and positive predictive value of gross cystic disease fluid protein-15 (GCDFP-15) and estrogen receptor protein (ERP) for diagnosing
P Viacava et al.
Virchows Archiv : an international journal of pathology, 432(3), 255-260 (1998-04-09)
GCDFP-15, a glycoprotein identified in the cyst fluid of cystic breast disease, is considered to be a marker of apocrine differentiation. Studies on GCDFP-15 localization in adult normal tissues are lacking, and no information on GCDFP-15 expression during fetal development
Diagnostic Immunohistochemistry: Theranostic and Genomic Applications, 227-228 (2014)
M R Wick et al.
Human pathology, 20(3), 281-287 (1989-03-01)
The identification of metastatic carcinoma of the breast may be difficult in the absence of a previous history of breast cancer. Various immunophenotypic markers have been introduced to aid in this process. A monoclonal antibody directed at a 15-kilodalton (kd)

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