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852678

Sigma-Aldrich

6-Mercaptopurine monohydrate

98%

Synonym(s):

6-Purinethiol, 6-Thiohypoxanthine

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About This Item

Empirical Formula (Hill Notation):
C5H4N4S · H2O
CAS Number:
6112-76-1
Molecular Weight:
170.19
Beilstein:
4012091
EC Number:
200-037-4
MDL number:
MFCD03854445
UNSPSC Code:
12352005
PubChem Substance ID:
24888330
NACRES:
NA.22

Assay

98%

form

powder

mp

>300 °C (lit.)

SMILES string

O.Sc1ncnc2[nH]cnc12

InChI

1S/C5H4N4S.H2O/c10-5-3-4(7-1-6-3)8-2-9-5;/h1-2H,(H2,6,7,8,9,10);1H2

InChI key

WFFQYWAAEWLHJC-UHFFFAOYSA-N

Gene Information

human ... PPAT(5471)

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General description

6-Mercaptopurine monohydrate is an antimetabolite and antineoplastic drug. Its cocrystallization with 4-hydroxybenzoic acid and 2,4-dihydroxybenzoic acid or salt formation with piperazine may improve its aqueous solubility.

Application

6-Mercaptopurine is a widely used antileukemic agent that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301,H341,H361fd

Hazard Classifications

Acute Tox. 3 Oral - Muta. 2 - Repr. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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The crystal and molecular structure of 6-mercaptopurine monohydrate.
Sletten E, et al.
Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials, 25(7), 1330-1338 (1969)
Goran Marinković et al.
Journal of immunology (Baltimore, Md. : 1950), 192(9), 4370-4378 (2014-03-29)
Azathioprine and its metabolite 6-mercaptopurine (6-MP) are well established immunosuppressive drugs. Common understanding of their immunosuppressive properties is largely limited to immune cells. However, in this study, the mechanism underlying the protective role of 6-MP in endothelial cell activation is
Unit-cell dimensions and space group of 6-mercaptopurine monohydrate.
Hoogsteen K.
Nature, 178(4529), 379-379 (1956)
Comparative structural and spectrum analyses of 6-mercaptopurine monohydrate and 6-mercaptopurine hydrochloride
Perez-Ruiz E, et al.
Canadian Journal of Analytical Sciences and Spectroscopy, 43(3), 59-67 (1998)
M J Casanova et al.
The American journal of gastroenterology, 108(3), 433-440 (2013-01-16)
The safety of thiopurines and anti-tumor necrosis factor-α (TNF-α) drugs during pregnancy remains controversial, as the experience with these drugs in this situation is limited. Our aim is to assess the safety of thiopurines and anti-TNF-α drugs for the treatment
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